Cell proliferation was increased and apoptosis was reduced in SMMC-7721 cells overexpressing miR-499b-5p and hsa_circ_0004658, and the opposite occurred when either hsa_circ_0004658 or miR-499b-5p were inhibited (Fig. 6I–K), leading to the assumption that hsa_circ_0004658 inhibits proliferation and promotes apoptosis in HCC cells by sponging miR-499b-5p and downregulating JAM3 expression. This evidence concerns the gene JAM3 and hepatocellular carcinoma.