In the tumors overexpressing RBPJ+/+ Mφ-Exo tumors were significantly smaller than all other tumors, therefore the upregulation of hsa_circ_0004658, which leads to the downregulation of miR-499b-5p and the upregulation of JAM3, results in a tumor-suppressive phenotype in the mouse HCC model. The gene discussed is RBPJ; the disease is neoplasm.