In this study, we investigate the effects of macrophage-derived exosomes overexpressing RBPJ (RBPJ+/+ Mφ-Exo) on proliferation and apoptosis in HCC cells and compared them to exosomes from THP-1-like macrophage (WT Mφ-Exo) [31]. The gene discussed is RBPJ; the disease is hepatocellular carcinoma.