CCND3 and precursor B-cell acute lymphoblastic leukemia: To this end we transfected NALM-6 and RS4;11 B-ALL cells with a reporter construct driven by the CCND3 promoter spanning from −1389 to +259 bp from the transcriptional start site (TSS) and harboring the FOXO binding motif GTAAACA −126 bp from the TSS (“long”) [19] (Fig. 2C).