Comparing the transcriptome changes induced by CCND3 knockdown versus palbociclib, we identified CDK8 among the genes exclusively repressed by CCND3 knockdown and demonstrated that knockdown of CDK8 induces apoptosis in B-ALL cell lines harboring ETV6-PDGFRB and MLL-AF4 translocations. This evidence concerns the gene CCND3 and acute lymphoblastic leukemia.