Palbociclib increased FOXO1 protein expression (Supplementary Fig. 6A) and concomitantly increased Ccnd3 expression at mRNA (Supplementary Fig. 6B) and protein levels (Supplementary Fig. 6C) suggesting that also E2Fs are not essential for Ccnd3 transcription in B-ALL. The gene discussed is FOXO1; the disease is precursor B-cell acute lymphoblastic leukemia.