Interestingly, although it was documented that palbociclib is not able to induce apoptosis in B-ALL, genetic depletion, or a PROTAC-dependent degradation of CDK6, the predominantly expressed CDK that forms a holoenzyme with CCND3, induces cell death in BCR­ABL1+ B-ALL. This evidence concerns the gene CDK6 and acute lymphoblastic leukemia.