For all indexed B-ALL cell lines (SEM, SEMK2, 697, RCH-ACV, REH, JM-1, NALM-6, HB1119, and P300HK), estimated dependency on CCND3 was much higher than for CCND1 and CCND2 (Supplementary Fig. 2A, B). The gene discussed is CCND1; the disease is acute lymphoblastic leukemia.