This position statement recommends that in patients with T2D at very high risk of CVD (as defined by the presence of clinical atherosclerotic disease, with previous CV events), the addition of a glucose-lowering agent (GLA) with demonstrated CV benefit, namely a sodium-glucose co-transporter-2 inhibitor (SGLT2i) or glucagon-like peptide-1 (GLP-1) analog, can be useful to reduce CV risk [9]. The gene discussed is GCG; the disease is type 2 diabetes mellitus.