For example, PAK1 is a predicted risk gene with 6 criteria of biological evidence: high brain expression specificity (z-score = 1.01), supportive experimental evidence from the literature, druggable target data, and differential expression in human brain of AD patients, microglial cells of 5XFAD mouse model, and brain hippocampus of a tau mouse model (Fig. 3 and Table S8). This evidence concerns the gene MAPT and Alzheimer disease.