Samples from NB xenograft tumors (IMR-32 and SK-N-SH) reflected a similar behavior as with the cultured cells with respect to HuD, GRB-10, ND1 and miR375: HuD silencing reduced the levels of GRB-10 and ARL6IP1 RNA and increased the expression of ND1 and miR375 (Fig. 8I and J). The gene discussed is ARL6IP1; the disease is neuroblastoma.