Knockdown of endogenous HuD or overexpression of FLAG-HuD led to opposite changes in pS6 levels in IMR-32 cells (Fig. 2F) and NB mouse xenograft tumor samples showed HuD level changes inversely correlating with the mTORC1 activity marker pS6K (Fig. 3A). This evidence concerns the gene ELAVL4 and neuroblastoma.