As regards to our findings for the polygenic risk scores and subsite-specific CRC risks, stronger involvement of the mTOR-PI3K-Akt pathway in the development of more proximally located colorectal tumors is plausible considering that higher (over)expression of Akt1, Akt2, and p-p70S6K(Thr389) genes has been reported in proximal colon tumors than distal colon tumors. This evidence concerns the gene AKT2 and colorectal carcinoma.