In this regard, a posttranscription form of DENND1A, DENND1A.v2, is over-expressed in some women with PCOS [73], while experimentally-induced DENND1A.v2 over-expression in human theca cells increases androgen biosynthesis and release as a fundamental PCOS trait linked to metabolic dysfunction. The gene discussed is DENND1A; the disease is polycystic ovary syndrome.