Such preferential abdominal fat accumulation in hyperandrogenic PCOS women underlies insulin resistance over a wide BMI range [25], and also occurs in healthy normal-weight PCOS women by NIH criteria in combination with adipose insulin resistance (adipose-IR), defined by the product of fasting circulating free fatty acid (FFA) and insulin levels [19, 24, 26]. The gene discussed is INS; the disease is Insulin resistance.