To further explore the function of YES1 affecting cisplatin sensitivity in ovarian cancer, we screened for a highly efficient Yes1 knockdown siRNA by measuring the silencing efficiency of three YES1 siRNAs with different targeting sequences in SKOV3-DDP or A2780-DDP cells (Additional file 1: Fig. S2), si-YES1#2 (referred to as siYES1 in the subsequent experiments) transfection in A2780-DDP and SKOV3-DDP ovarian cancer cells significantly downregulated YES1 expression at both the mRNA and protein levels (Fig. 3C and D). The gene discussed is YES1; the disease is ovarian cancer.