Moreover, rapamycin, an autophagic agonist, reversed siYes1-induced cisplatin resistance, and chloroquine, an autophagy antagonist, reversed Yes1-OE-induced cisplatin resistance (Fig. 5I, J), which further demonstrated that YES1 affects cisplatin resistance in ovarian cancer by regulating cell autophagy. The gene discussed is YES1; the disease is ovarian cancer.