SLC5A8 and amyotrophic lateral sclerosis: High concentrations (6–36 mM) of drugs such as ibuprofen, SA, and edaravone were needed to block the biological process of the [3H]VPA uptake by half in the MT ALS cell line (Fig. 8) SA is a strong inhibitor, and ibuprofen is a competitive blocker of an SMCT; hence, the IC50 values of both compounds were in a low range, and both are competing for binding with a transportable substrate [30].