Similarly, MCT substrates/inhibitors, such as acetic acid (AA), SA, 4-phenylbutyric acid (PBA), and α-cyano-4-hydroxycinnamate (CHC) at concentrations of 1 and 10 mM strongly inhibited the VPA uptake in both WT and MT ALS cell lines compared with that in the respective controls. The gene discussed is SLC16A1; the disease is amyotrophic lateral sclerosis.