VEGFA and Familial prostate cancer: Using the cis-pQTL instrument selection criteria, we found evidence of a positive association between genetically proxied concentrations of MIP1a and overall prostate cancer risk (1.06, 1.03 to 1.1, p = 5.62 × 10−4) and for an inverse association between genetically proxied vascular endothelial growth factor (VEGF/VEGFA) concentrations and risk of advanced prostate cancer (0.86, 0.79 to 0.93; p = 2.28 × 10−4).