Using the cis-pQTL instrument selection criteria, we found a positive association between genetically proxied circulating concentrations of cutaneous T-cell attracting chemokine (CCL27/CTACK) and lung cancer risk in never smokers (2355 cases, 1.51, 1.22 to 1.87, p = 1.73 × 10−4) and inverse associations between genetically proxied interleukin-18 (IL-18/IL-18) concentrations and overall lung cancer (0.87, 0.81 to 0.93, p = 9.9 × 10−5) and lung adenocarcinoma (0.80, 0.73 to 0.89, p = 1.41 × 10−5) (Figs. 2, 3﻿ and 4; Additional file 2: Tables S5 & S6). Here, CCL27 is linked to lung cancer.