Of relevance to migraine pathophysiology, TRPM3 channels co-localize in TG neurons with the nociceptive fibre neuropeptide calcitonin gene-related peptide (CGRP) [16], of which plasma levels were shown to be elevated during migraine headache [17] and antagonism of CGRP has proven effective in treating migraine [18]. Here, TRPM3 is linked to migraine disorder.