Moreover, murine study results suggest arelation between P. Aeruginosa and insulin metabolism as it wasfound that acute P. Aeruginosa colonization induced insulin resistance.56 Poorer neuromuscular skills, especially during adolescence, as reported byGruber et al.57 could be another factor to take into consideration for lower CRF and physicalactivity levels, especially engaging in higher intensities. This evidence concerns the gene INS and Insulin resistance.