A HR of 1.31 (95% CI, 1.10–1.56, P=0.003) per SD decrease in F2RL3 DNA methylation at CpG_1 in current smokers (from the fully adjusted model) suggests that observationally, F2RL3 DNA methylation is associated with outcome following a myocardial infarction in this subgroup (Table S4A). This evidence concerns the gene F2RL3 and myocardial infarction.