TRIM21 and cryoglobulinemia: Beyond their use as a diagnostic criteria, the presence of anti-SSA antibodies has been associated with early onset disease, more signs of B cell activity (hypergammaglobulinemia, rheumatoid factors, cryoglobulinemia, and naive/memory B cell imbalance), and more extraglandular manifestations in pSS [7,9,10,11,12,13]: Raynaud phenomenon [14], interstitial pneumonia [15], peripheral nerve involvement [14,16,17,18], cutaneous vasculitis [19,20,21,22], cytopenias [16,19,23,24], adenopathies [14,19,25], and lymphoma [12,25,26].