In this study, 309,056 patients newly initiated on either SGLT2 inhibitors, including empagliflozin, canagliflozin and dapagliflozin, or other glucose lowering drugs were analyzed on the risk for hospitalization for heart failure and death in patients with T2DM, using clinical data in real-world practice after propensity score matching [101]. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.