F3 and neoplasm: A number of prothrombotic mechanisms have been proposed to explain cancer-related coagulopathy, which include the initiation of the extrinsic pathway by clotting initiator protein (tissue factor) and polyphosphate (polyP) in circulating tumor-derived extracellular vesicles (EVs), and the interaction of tumor-derived EVs with platelets or neutrophil extracellular traposis (NETosis) [3].