The most frequently observed platelet dysfunctions associated with haematological diseases are: inadequate platelet aggregation to ADP, epinephrine or collagen; low nucleotides secretion; low serotonin secretion; a decrease in thromboxane production and low PDGF and beta-thromboglobuline production [42,43,44,45]; the overproduction of cAMP [46]; and platelet signalling defects. Here, PPBP is linked to hematologic disorder.