APCr with both the ST Genesia and the CAT using Protac®, but not the CAT using rhAPC, was significantly greater in triple antiphospholipid antibody (aPL) APS patients compared to double/single aPL patients and in thrombotic SLE patients compared to non-thrombotic SLE patients. The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.