According to the APS classification (categories: I, IIa, IIb, and Iic, based on Miyakis et al., 2006) [22], 64/105 APS patients were category I (more than one laboratory criteria present; 45 of whom were double and 19 triple aPL positive); 16 were category IIa (LA alone), 11 were category IIb (presence of aCL alone); 14 patients were category IIc (presence aβ2GPI alone). Here, ACLY is linked to autoimmune polyendocrinopathy.