TNF and allergic disease: Indeed, in their 10-year follow-up cohort study conducted in an Asian population, Chang et al., (2016) have demonstrated an increased risk of allergic diseases in AS; additionally, the authors raised the question about how DMARDs may influence the expression of atopic disorders in such patients, since biologic agents, particularly TNF inhibitors (TNFis), might affect the Th1/Th2 balance [8,17].