In our study, we obtained similar results to those obtained by Pidasheva et al., Di Meglio et al. and J.C Nossent et al. [24,59,60], confirming the association of IL-23- R381Q polymorphism with MS under the codominant model after adjustment for age, gender and smoking factors as covariates, as well as after correcting for multiple testing using the FDR method. This evidence concerns the gene IL37 and myeloid sarcoma.