Several cohorts investigated the impact of mutations in single genes on clinical parameters or success of surgery, but merely included distinct mutations such as CYP1B1, MYOC or LTBP2 in PCG [27,28,29,30,31,32,33,34,35,36,37,38,39] or focused on individual syndromes possibly leading to secondary childhood glaucoma such as Axenfeld–Rieger anomaly [11,40] or Aniridia [41]. This evidence concerns the gene CYP1B1 and glaucoma.