NR1H4 and coronary artery disorder: Recent human genetic evidence indeed supports a role for FXR (encoded by the NR1H4 gene) in plasma lipid metabolism: a common NR1H4 variant (rs35724 G>C) was found to be linked with a higher serum cholesterol [26], while a rare missense NR1H4 variant (pro.R436H) was found to be associated with lower cholesterol levels and protection against coronary artery disease [27].