APOB and type 2 diabetes mellitus: Another study that compared metformin plus placebo to metformin plus colesevelam (3.75 g/d) in 286 patients with T2D showed almost identical results: significantly decreased HbA1c (−0.3%), total cholesterol (−6.1%), LDL-C (−16.3%), non-HDL-C (−8.3%) and apoB (−8.0%), while triglycerides increased (+18.6%) [85].