CTNS and cystinosis: To elucidate the molecular pathways altered in cystinosis due to complete CTNS loss, we performed a pathway analysis that revealed the pathways significantly correlated (p < 0.05) with CTNS loss: ubiquinone biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, arginine biosynthesis, cystine and methionine metabolism, D-Glutamine and D-glutamate metabolism, alanine, aspartate and glutamate metabolism, and the TCA cycle (tricarboxylic acid cycle), in decreasing order of impact.