In line with the important role of TENM4 in central nervous system development, ODZ4 has been identified as a risk gene for many types of mental diseases, including bipolar disorder (Psychiatric GWAS Consortium Bipolar Disorder Working Group, 2011) [28,29,30], schizophrenia [31,32], and autism [33]. This evidence concerns the gene TENM4 and schizophrenia.