CDKN2B and urinary bladder carcinoma: Conversely, increased cell proliferation and colorectal cancer cell invasion is mediated by the targeting of the Cyclin-Dependent Kinase inhibitor 2B (CDKN2B) by miR-708 [66], while, in bladder cancer the targeting of Caspase-2 by miR-708 reduces cell apoptosis [67].