Moreover, high TENM4 protein expression has been detected in different human and mouse breast cancer cell lines, including Estrogen Receptor (ER), Human Epidermal growth factor-2 (HER2), and positive and Triple Negative Breast Cancer (TNBC) subtypes (BT474, MCF-7, MDA-MB-231, T47D, HCC-1806, 4T1, and ZR7S) [43,75]. This evidence concerns the gene ESR1 and breast carcinoma.