NNAT and Familial prostate cancer: For instance, in prostate cancer, miR-708 downregulation induces, on one hand, increased Karyopherin α4 (KPNA4) expression, increasing cancer cell metastatization; however, on the other hand, the reduced targeting of pro-tumorigenic proteins such as CD44, AKT serine/threonine kinase 2 (AKT2), and Neuronatin (NNAT) increases cells malignancy [54,55].