In the myocardium of patients with TF, high levels of methylation of the NKX2-5 and HAND1 promoters [130] and low levels of methylation of the TBX20 promoter are found in comparison with the control group, which is regarded as one of the factors in the pathogenesis of this CHD [130,131,132]. The gene discussed is TF; the disease is coronary artery disorder.