MLKL and cancer: In contrast, a genetic knockout of the major necroptotic players such as RIPK-1, RIPK-3, or MLKL leads to a significant attenuation of tumor growth both in vitro and in vivo as well as to an increase in the radiosensitivity of cancer cells via a marked decrease in both the NF-κB activity and the secretion of pro-inflammatory cytokines [28].