MAPT and Alzheimer disease: In particular, p38 MAPK is stimulated by phosphorylated tau, normal dephosphorylated tau, and Aβ oligomers, leading to inflammatory signalling and activation of microglia in AD and inhibition of p38 MAPK pathways, successfully reducing Aβ and memory loss in AD mice [56,57,58,59,60] and suggesting this MAPK signalling as an important therapeutic target.