Based on the convergent findings of Gtf2i-specific gene-dose-dependent social and anxiety phenotypes in murine models [47,48], which are similar to those observed in the human hemideletion and duplication syndromes [49,50,51], we decided to focus on Gtf2i in order to study novel neurobiological mechanisms governing behavioral and neurobiological alterations. This evidence concerns the gene GTF2I and Anxiety.