These results indicate that silencing of either BdPGRP-LB, BdPGRP-SB or BdPGRP-SC2 will induce overactivation of the Imd pathway upon bacterial infection, as all these three BdPGRPs perform negative regulatory roles in regulating AMPs gene expression in the Imd pathway of B. dorsalis. The gene discussed is ADSL; the disease is bacterial infectious disease.