As TGF-β and NPNT are dysregulated in different glomerular diseases [10,11,12,13,14,15,16,17,19,20,21,22,23], our results of a TGF-β-mediated NPNT regulation, facilitated mainly by non-canonical pathways and post-transcriptional mechanisms, might have important impact for the development of novel therapeutic strategies in the future. Here, NPNT is linked to glomerular disorder.