This inverse correlation was previously reported in the 3xTg-AD mouse model where hyperbaric oxygen therapy was shown to reduce gliosis in parallel with the decrease of pro-inflammatory cytokines (IL-1β and TNF-α) and the increase of Arginase 1 and anti-inflammatory cytokines (IL-4 and IL-10) [77]. The gene discussed is ARG1; the disease is Alzheimer disease.