In the present study, the diminished expression of CD11b, CX3CR1, MFG-E8, TNF-α and IL-1β gene levels in the brain cortices and hippocampi, with a more robust decrease for the last two genes, together with the decrease of HMGB1 protein and the pro-inflammatory genes IL-6 and IL-18 only in the cortex, validate the presence of an immunosuppressed microglia in the young 3xTg-AD animals and their failure in preventing AD plaque pathology [75]. This evidence concerns the gene HMGB1 and Alzheimer disease.