Considering that microglia homeostatic/reactive genes were found depressed based on the expression of the CD11b, CX3CR1 and MFG-E8 markers, and since inflammatory genes were found downregulated in the SOD1G93A mouse model of amyotrophic lateral sclerosis before disease onset [45], we next assessed a set of inflammatory genes associated with neuroinflammation in neurodegenerative diseases. Here, CX3CR1 is linked to neurodegenerative disease.