Increased levels of HMGB1 (both regions), of CX3CR1 (brain cortex) and of iNOS, TNF-α, IL-1β, IL-6, SOCS1 and Arginase 1 (hippocampus) were present in 9-month-old 3xTg-AD animals. The gene discussed is IL1B; the disease is Alzheimer disease.