We report a reduction of CD11b, C-X3-C motif chemokine receptor 1 (CX3CR1) and milk fat globule-EGF factor 8 (MFG-E8) gene expression levels in the cortex and hippocampus of 3-month-old 3xTg-AD animals, as well as a decrease of inflammatory cytokines (TNF-α and IL-1β in both regions and IL-6, IL-18 and HMGB1 only in the brain cortex). This evidence concerns the gene IL18 and Alzheimer disease.