Curiously, when evaluating the expression of anti-inflammatory cytokines (Figure 4E,F), while IL-10 was reduced in the cortex of 3-month-old 3xTg-AD mice (0.7-fold, p < 0.05), IL-4 expression was enhanced in samples from the same region and age (1.7-fold, p < 0.01) but markedly downregulated in the cortex of 9-month-old 3xTg-AD mice (1.3-fold in 3xTg-AD vs. 4.6-fold in WT mice, p < 0.05). This evidence concerns the gene IL10 and Alzheimer disease.