Cystic Fibrosis (CF; OMIM: 219700) is a life-shortening inherited disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein [1], a cAMP-regulated chloride (Cl−) and bicarbonate (HCO3−) channel expressed at the apical plasma membrane (PM) of secretory epithelia. Here, CFTR is linked to cystic fibrosis.