The inhibition of autophagy by a combination of a mechanistic target of rapamycin kinase (mTOR) and a lysosomal inhibitor resulted in RIPK1-dependent necroptosis in human renal carcinoma cell lines [66], while GX15-070-induced autophagy was reported to recruit Fas associated via death domain (FADD)/RIPK1/RIPK3 to the autophagosomal membranes in rhabdomyosarcoma cells [67]. The gene discussed is RIPK1; the disease is renal carcinoma.