MYOM2 and plasma cell myeloma: Diagnosis of SMM now requires the absence of myeloma-defining events [1], specifically the CRAB features and nonrecurrent bacterial infections, as well as serum M-protein (IgG or IgA) ≥ 3 g/dL or urinary M-protein ≥ 500 mg/24 h and/or 10–60% clonal BMPCs.