The role of GILZ as an inhibitor of immune and inflammatory responses mediated by T lymphocytes has been confirmed by studies that have detected GILZ expression in the synovium of humans with rheumatoid arthritis (RA) and of mice with collagen-induced arthritis (CIA), the severity of which is enhanced by GILZ silencing [13,60]. The gene discussed is TSC22D3; the disease is rheumatoid arthritis.