IL-1β and IL-6 participate in inducing IL-8 expression in polymorphonuclear leukocytes (PMNs), which in turn enable the extravasation of MCs [108].TANs are neutrophils engaged at tumor site and can be anti-or pro-tumor phenotypes, N1-TANs and N2-TANs, respectively [109]. This evidence concerns the gene CXCL8 and neoplasm.