For melanoma, the data showed the followings: (a) in culture supernatants, IL-8 levels were quantitatively correlated with MC numbers and mRNA for IL-8 was increased in hypoxic state; (b) inxenografts IL-8 serum levels were precisely correlated with tumor volume and upon excision its level dropped; (c) the patient serum levels were correlated with tumor size and stage; (d) IL-8 levels can be used to monitor tumor stage following treatments with different combinatorials which do not target its expression directly. This evidence concerns the gene CXCL8 and melanoma.