The FKBP51 analysis in melanoma demonstrated that: FKBP51 regulates IL-8 through the activation of NF-kB, and in turn, IL-8 mediates in part FKBP51-regulated melanoma growth, aggressiveness and the effect of FKBP51 on angiogenesis in melanoma. The gene discussed is CXCL8; the disease is melanoma.