The drug efflux transporter ABCB5 (ATP-binding cassette, sub-family B (MDR/TAP member 5) is another controller of IL-8 expression in melanoma cells through a mechanism that involves whey acidic protein 4-disulphide core domain 1 (WFDC1/ps20) and Wnt pathway [95]. This evidence concerns the gene WFDC1 and melanoma.