Although not directly related to IL-8-mediated pathways, TAMs in melanoma can be targeted by trabectedin, an antineoplastic drug, which induces death of monocytes/macrophages via a TNF-related apoptosis-inducing ligand (TRAIL)-mediated mechanism, restricting thus melanoma growth and metastasis via reducing the number of TAMs in the tumor microenvironment [217]. The gene discussed is TNFSF10; the disease is melanoma.