In non-small cell lung cancer cell lines (A549 and NCI-H292) selective inhibitors of MAPK branches demonstrated that IL-8 induces transactivation of EGFR and stimulation of ERK1/2, but not of p38 MAPK, resulting in tumor cell proliferation and involving the expression of a MMP located at PM [138]. Here, CXCL8 is linked to neoplasm.