CXCL8 and neoplasm: In ameloblastoma, a common odontogenic epithelial tumor in the maxillofacial area, in tumor cells IL-8 could promote EMT by decreasing expressions of E-cadherin, increasing phosphorylation of β-catenin and the expressions of EMT-specific transcription factors, twist and zeb1, and of EM -marker, vimentin [154].