The IL-8 involvement has been deciphered in relation with the ERK pathway in SK-OV-3 ovarian cancer cells [137], where it has been found that stimulation with IL-8 activated Ras-dependent MAP kinase pathway via phosphorylated EGF receptor (EGFR) associated with adaptor molecules Shc and Gbr2. This evidence concerns the gene CXCL8 and ovarian carcinoma.