Bielamowicz et al. [14] demonstrated that nearly 100% of tumor cells were killed, in vitro and in vivo, with UCAR-T, a trivalent transgene combining IL13Rα2 binding IL-13 mutein, HER2-specific single chain variable fragment 9scFv), FRP5, and Epha2-specific scFv 4H5 with CD28 as a costimulatory molecule and ζ-signaling domain of the T cell receptor (TCR). This evidence concerns the gene CD28 and neoplasm.