PPARGC1A and amyotrophic lateral sclerosis: Studies had shown that PGC-1α is involved in the pathophysiology of Huntington’s disease (HD) [17], Parkinson’s disease (PD) [18], and Alzheimer disease [19], amyotrophic lateral sclerosis (ALS) [20], and neuropsychiatric disorders such as schizophrenia [21,22] (reviewed in [23,24,25]).