Besides the AhR, other xenobiotic receptors such as CAR or PXR regulate or target the mitochondrial functions but the number of studies is much lower than the ones involving the AhR: a recent work shows that PXR (pregnane X receptor) targets an enzyme, the aldo-keto reductase family 1, member B7 (AKR1B7), which significantly improves mitochondrial function in acute kidney injury (AKI). Here, NR1I2 is linked to acute kidney injury.