IL33 and asthma: For example, it has been recently shown that TSLP, an epithelial derived cytokine involved in asthma, that activates the JAK/STAT and the PI-3 kinase pathways, and IL-33 synergistically promoted group 2 innate lymphoid cell (ILC2) activation by reciprocally increasing their expression and the expression of their receptors on pulmonary ILC2 in vivo and in vitro, following Alternaria alternata challenge to enhance innate type-2 airway inflammation [102].