Moreover, numerous studies have shown synergy between lipid mediators such as leukotrienes, which signal through nuclear factor of activated T-cell (NFAT) and IL-33 that activates AP-1 and NFkB pathways on ILC2s responses and type 2 inflammation, in various models, such as Nippostronglyus brasiliensis parasite infection model or during allergen challenge with Alternaria alternata [103,104,105,106]. Here, IL33 is linked to parasitic infectious disease.