TNF and type 2 diabetes mellitus: On the other hand, we have reported that T2D mice develop histological signals of non-alcoholic steatohepatitis (NASH, according to NASH-CRN Pathology Committee System), associated with impaired glucose metabolism in the liver, and increased expression of the inflammatory markers TNF, IL6 and NFKB, as well as increased binding activity of nuclear proteins in NFKB-binding site target genes, as measured in the Slc2a2 (solute carrier family 2 member 2) gene [123].