Participation of the NFKB-mediated inflammatory activity in Slc2a4 mRNA expression was further confirmed by (1) the anti-inflammatory effect of atorvastatin in adipose tissue of T2D mice [62]; (2) the insulin sensitizer effect of inhibition of cannabinoid receptor 1 in 3T3-L1 adipocyte [63]; (3) the dose-dependent insulin-induced enhancement of the Slc2a4 expression in soleus muscle [64]; and (4) the oleic and linoleic fatty acids-induced repression of the Slc2a4 expression in L6 muscle cell [65]. Here, INS is linked to type 2 diabetes mellitus.