SLC2A4 and diabetes mellitus: Considering that AGEs can participate in both the impairment of glycemic homeostasis and the development/progression of chronic complications of DM, and considering that these effects involve ER stress- and inflammatory-mediated pathways, the present manuscript reviews these regulations upon the expression of solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) expression, as a marker of altered glycemic homeostasis [11,12,13] and, upon atherogenesis, as an important inducer of the development/progression of CVD [7].