IRAK1 and Alzheimer disease: In this sense, the present work aimed to assess the genetic profile of key players associated with the TLR pathway, i.e., TIR domain-containing adaptor protein (TIRAP), MyD88, IRAK1, TNF receptor-associated factor 6 (TRAF6), NFκB inhibitor alpha (IκBα) and NFκB in a stimulated model of AD and after treatment with osthole, in order to evaluate the changes in gene expression signature and secretion of CKs and ChKs.