TET2 and inflammation: Hence, although Tet2 inhibits the production of various cytokines in tissue macrophages from different organs, its role in mice in vivo is more limited, likely due to cytokine production by other cell types, which may also explain the lack of differences between Tet2fl/flLysMCre and control mice in other inflammatory and injurious responses during LPS-induced lung and peritoneal inflammation and E. coli peritonitis.