PAX2 and neoplasm: Similarly, E2 and the synthetic progestin R5020 have been shown to promote the binding of PR and the transcriptional factor Paired box gene 2 (PAX2) in Ishikawa endometrial cancer cells, resulting in enhancer-promoter interacting loops within a TAD with HCRs, which contains several tumor development genes such as HMGA2, ETV4, ETV7, and GZMB [68].