Structural TAD alterations or inter-TAD modifications occur in the cancer genome by different mechanisms, including alteration to CTCF (mutations, aberrant DNA methylation, or post-transcriptional modification) [43,50,51,52], cancer-risk single nucleotide polymorphisms (SNPs), viral integration, hormonal response, and structural variants (SVs), such as deletions, insertions, inversions, duplications, or translocations [53,54]. The gene discussed is CTCF; the disease is cancer.