A multitude of transcriptional repressors derived from tumor-associated reactive stroma play crucial roles in the regulation of signaling pathways affecting neoplastic cells and inducing EMT, including the zinc finger E-box binding homeobox 1 (ZEB) protein family, the Twist protein family, and the Snail protein family [9,16,18,19,20,21,22,23,24,25]. This evidence concerns the gene ZEB1 and neoplasm.