Moreover, the mTOR pathway is activated in experimental PAH animal models induced by hypoxia, MCT, and Su5416/hypoxia (Su/Hx) rat models, which are associated with the development of pulmonary vascular remodeling and right ventricle (RV) remodeling and dysfunction [21,22,23] Thus, activation of the ROCK and Akt/mTOR pathways plays important roles in PAH development, and inhibition of these pathways may be a new strategy for treating PAH. Here, AKT1 is linked to pulmonary arterial hypertension.