In conclusion, H-1337 and H-1337M1 exert inhibitory effects on the ROCK and mTOR pathways in hPASMC and the pulmonary vasculature in Su/Hx rats and may contribute to attenuation of pulmonary hypertension and remodeling of the pulmonary vasculature and RV in Su/Hx rats. Here, MTOR is linked to pulmonary arterial hypertension.