These latter observations also provide some potential clues into the pathogenesis of this unique hyper-inflammatory disorder, since TRBV11-2 has been associated with autoreactive T cells that recognize non-peptide antigens in the context of non-classical HLA molecules, and Granzyme A can contribute to both cytotoxicity and inflammation by virtue of its ability to cleave pro-IL-1, and ITGB7 is a gut-homing integrin molecule subunit (abdominal involvement is a key feature of the clinical presentation in MIS-C patients) [68]. The gene discussed is ITGB7; the disease is COVID-19–associated multisystem inflammatory syndrome in children.