Significant skewing of the T cell receptor (TCR) repertoire in favor of TRBV11-2 in both CD4+ and CD8+ memory T cells, as well as the enhanced expression of Granzyme A in CD45RA+ effector memory CD8 T cells (TemRA) and ITGB7 in memory CD8 T cells have also been noted in MIS-C patients [68]. Here, GZMA is linked to COVID-19–associated multisystem inflammatory syndrome in children.