NR1I2 and primary biliary cholangitis: Based on Wunsch and colleagues’ findings, only in PBC patients was the overexpression of PXR in line with the enhanced transcriptional activity of SULT2A1, whereas PXR activation seems not to be responsible for increased levels of SULT2A1 in PSC patients, suggesting a disease-specific transcriptional effect of PXR on this enzyme [57].