While alterations in PXR gene expression are known to play a significant role in the prognosis of PSC, a study by Poupon and collaborators demonstrated that the genetic background of PXR, specifically a single nucleotide polymorphism (SNP) C/A in exon 9 of 3′-UTR of NR1L2/PXR, is weakly correlated with the progression and severity of PBC [47]. Here, NR1I2 is linked to primary biliary cholangitis.