MTOR and retinitis pigmentosa 1: In all four models of RP, the molecular machinery underpinning mTOR inhibition-dependent cones’ degeneration includes a particular form of autophagy, namely, chaperone-mediated autophagy (CMA), as evidenced by cone-specific increased levels of LAMP2A, a common marker of CMA typically activated upon a prolonged period of starvation [61].