CFTR and chronic pancreatitis: Genes in which mutation confers an increased risk of developing (chronic) pancreatitis are grouped in three categories: (1) the trypsin-dependent pathway including PRSS1, PRSS2, SPINK1, CTRC and CTRB1 [62,63,64]; (2) the misfolding-dependent pathway including CPA1 [65] and CEL [66]; and (3) the ductal pathway which, aside from CFTR, includes CLDN2 and CASR [5].